Q1. Most common extraintestinal manifestation of Crohn's disease of small bowel is.
a) Ankylosing Spondylitis
b) Erythema Nodosum
c) Iritis
d) Ureteral Obstruction
Q2. Which of the following is the most common cause of death in Crohn's disease
of small bowel
a) Malignancy
b) Sepsis
c) Electrolyte Disorders
d) Thromboembolic Phenomenon
Q3. Which of the following is not true about Pneumatosis intestinalis of small bowel?
a) It is seen equaly and males and females
b) Most common location is subserosa in the jejunum
c) Operative Procedures are required in most of the cases
d) It is associated with COPD and immunodeficiency states
Q4. What is not true about blind loop syndrome?
a) It manifets as diarrhoea, weight loss and deficiency of fat soluble vitamins.
b)Megaloblastic anemia is commonly seen
c)Surgery is almost always required to correct small bowel syndrome
d) Broad spectrum antibiotics are the treatment of choice
Q5. What is not true about the immune mechanism in the small bowel?
a) Intestine contains more than 70% of IgA producing cells in the body
b)Ig A acts by activating the complement pathway
c)Ig A is produced by plasma cells in the lamina propria
d)Approximately 60% of the lymphoid cells are T cells
Answers
1.b
Crohn’s disease is the most common primary surgical disease of the small bowel. Incidence of Crohn's disease is 3-7 /100,000.
Extraintestinal manifestations of Crohn’s disease may be present in 30% of patients. Skin lesions are the most common extraintestinal manifestations unlike in Ulcerative Colitis where Arthritis is more common.
Symptoms may precede, accompany, or appear independent of the underlying bowel disease.
Sabiston 17th 1345
2. a
Crohn’s disease primarily attacks young adults in the second and third decades of life. However, a bimodal distribution is apparent with a second smaller peak occurring in the sixth decade of life. Crohn’s disease is more common in urban dwellers, and although earlier reports suggested a somewhat higher female predominance, the two genders are affected equally. The risk of developing Crohn’s disease is about two times higher in smokers than that in nonsmokers
Death rate in a person with Crohn's disease is 2-3 times higher than general population. Most common cause is malignancy of the small intestine and not any inflamatory condition.
Sabiston 17th page 1097
3. c
Operation is not required unless a complication such as volvulus, hemorrhage, intestinal obstruction or perforation develops.
Complications are seen in lesss than 3% cases.
On plain Xrats they appear as radioluscent areas in the ball wall which have to be distinguished from luminal intestinal gas
Sabiston 18th edition page 1326
4.c
Blind lop syndrome is manifetsed by diarrhea, steatorrhea, megaloblastic anemia, weight loss, abdominal pain, and deficiencies of the fat-soluble vitamins (A, D, E, and K), as well as neurologic disorders.
It is caused by bacterial overgrowth in stagnant areas of the small bowel due to stricture, stenosis, fistulas, or diverticulum.
Surgery is required in very few cases'
Surgical correction of the condition producing stagnation and blind loop syndrome produces a permanent cure and is indicated in those patients who require multiple rounds of antibiotics or are on continuous therapy.
Bacterial overgrowth can be diagnosed with cultures obtained through an intestinal tube or by indirect tests such as the 14C-xylose or 14C-cholylglycine breath tests. Once bacterial overgrowth and steatorrhea are confirmed, a Schilling test (57Co-labeled vitamin B12 absorption) may be performed next, which should reveal a pattern of urinary excretion of vitamin B12 resembling that of pernicious anemia (a urinary loss of 0% to 6% of vitamin B12 compared with the normal of 7% to 25%
5. b
The intestine contains more than 70% of the IgA-producing cells in the body.
IgA is produced by plasma cells in the lamina propria.
IgA does not activate complement and does not enhance cell-mediated opsonization or destruction of infectious organisms or antigens, which sharply contrasts to the role of other immunoglobulins.
Secretory IgA inhibits the adherence of bacteria to epithelial cells and prevents their colonization and multiplication. In addition, secretory IgA neutralizes bacterial toxins and viral activity and blocks the absorption of antigens from the gut.
