Paget disease of the breast

Q) A 60 year old lady, mother of 2 presents with rash and color change in the left areola of 3 months duration. She is diagnosed with Paget disease of the breast. What is true regarding this condition

a) Cancer is a distant possibility

b) Surgical therapy fails to cure Paget's disease of breast

c) Nipple biopsy is diagnostic

d) It is associated with paget's disease of bone

Answer

c

Paget's disease of the breast is invasive carcinoma which grows along the ducts into nipple and areola. Diagnosis is made by nipple biopsy. The lesion presents with eczematous rash which is persistent.

On histology swollen paget cells are seen. Surgical therapy is curative and this pathology is unrelated to paget's disease of the bone.