Tag: tropical pancreatitis

Tropical Pancreatitis

Tropical Pancreatitis

Q) All are true about tropical pancreatitis except?

a. Associated with Tapioca.
b. Patients have  large stones with fibrosis.
c. It is Pre Cancerous

d) Onset of disease at 50 years 


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Answer -d )Onset is at young age

Tropical pancreatitis

is an  idiopathic disease which begins in teens.  It has a high association with diabetes and Pancreatic duct calculi. It is common in South India, Asia, Africa and central America.

 

Etiology 

Malnutrition 

Cassava

Hydrocarbons exposure

It is associated with SPINK 1 mutation


It is pre cancerous

IPSG data shows the cumulative risk of Pancreatic Cancer  in patients with Chronic Pancreatitis  (predominantly of alcoholic aetiology) was reported as 1.8 % and 4 % at 10 and 20 years respectively. This risk was reported to be independent of age, sex and type of pancreatitis.

The link between CP and PC is clearer in certain subtypes of CP like tropical pancreatitis and hereditary pancreatitis.

 Augustine et al. reported a 8.3 % incidence of pancreatic cancer in patients with tropical pancreatitis, which is much higher than western figures.

Ref 

Pancreatic Cancer in Chronic Pancreatitis


Clinical Picture of tropical pancreatitis

a child, adolescent or young adult , recurrent upper abdominal pain, diabetes mellitus,  malnutrition, nutrient deficiencies, nutritional edema, cyanotic hue of the lips, parotid enlargement and pancreatic calculi on plain abdominal X ray  

Ref https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1742869/pdf/v079p00606.pdf

 

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