MCQ on General onco

Q) WHich is not a invasive mechanism of cancer cells invasion ?

a) Rise in interstitial pressure in the tissue

b) Dissolution of extracellular matix

c) Mobility of cells to Invade

d) Extra cellular matrix dissolution is due to  physical factors

Ans d 

Cancer cells secrete collagenases and proteases that chemically dissolve any extracellular boundaries
They also express  of cell-surface molecules called integrins

Three main mechanisms of cancer cells  that  facilitate invasion are

(1) Rise in the interstitial pressure within a tissue

2. They secrete enzymes that dissolve extracellular matrix

3. Acquire mobility

bailey 141

Differential diagnosis of mass in right iliac fossa

Q) Patient with generalized ill health and pyrexia has a mass in the right iliac fossa with a history of blood-stained mucoid diarrheia? Most common etiology in this case would be ? 

a) Carcinoma

b) TB

c) Amoeboma

d) Lymphoma

More questions on general surgery tropical infections

Ans  c

Amoeboma is partially treated amoebic infection of the caecum

It mostly presents as a mass in RIF and causes confusion with malignancy.

Such a patient is highly unlikely to have a carcinoma because altered bowel habit is not a feature of right-sided colonic carcinoma.

Ref Bailey page 58