Q) Anti Rejection medicine which also prevents tumor recurrence? MCH Questions ...
a) M tor inhibitors
b) IL2 blockers
Ans a) mtor inhibitors
One Question is always asked about anti rejection medicines, Salient points i am enumerating
Three drug regimen is classic includes IL2 blocker, Mycophenolate and steroids which are tapered . IL 2 blocker Tacrolimus is used more than Cyclosporine ( cyclosporine less used now). IL2 blocker side effects are hirsutism, hyperkalemia, gum hypertrophy etc)
Mycophenolate is preferred over azathioprine . Both cause fall in cell lines
Steroids have many side effects like weight gain, cataract, infections and are used in tapering dose
M-tor inhibitors are sirolimus and Everolimus which are used when transplant is done for HCC, IT has anti tumor action.
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