BRCA gene

5-10% of all breast cancers are hereditary

10% of those who develop early breast cancer (before 40) will have this mutation

Both Ovary and  breast involved at pre menopausal age and early

BRCA 1 - Associated with breast, ovary, colon, prostate

BRCA 2- In addition to above, bile duct, gall bladder, pancreas, gastric and malignant melanoma

BRCA 1- 17q21

BRCA 2- 13q

BRCA 1 are estrogen negative and BRCA 2 are estrogen positive