5-10% of all breast cancers are hereditary
10% of those who develop early breast cancer (before 40) will have this mutation
Both Ovary and breast involved at pre menopausal age and early
BRCA 1 - Associated with breast, ovary, colon, prostate
BRCA 2- In addition to above, bile duct, gall bladder, pancreas, gastric and malignant melanoma
BRCA 1- 17q21
BRCA 2- 13q
BRCA 1 are estrogen negative and BRCA 2 are estrogen positive