AIIMS ONCO 2020

CDH 1 gene

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Q) CDH 1 gene is associated with which cancer

a) Breast

b) Colon

c) Prostate

d) Renal

ANs a

CDH 1 is with gastric and lobular breast cancer

The CDH1 gene is responsible for  making a protein called epithelial cadherin or E-cadherin.

Germline mutation in the CDH1 gene encoding E-cadherin is  shown to be associated with hereditary diffuse gastric cancer. Also RHOA gene is also associated with Ca stomach

Prophylactic total gastrectomy should be considered in patients with these mutations

Renal cancer is mainly associated with VHL gene

Gene mutation associated with CDH 

E Cadherin is involved in

a) Cell Adhesion

b) Cell maturation

c) Managing intracellular chemical signals

d) It acts as a tumor suppressor protein

Cowden

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Q) Not seen in cowden syndrome
A. NET
B. Hamartoma
C. CA breast
D. Bowel malignancy

Malignancy risk in CS is significant outside the GI tract. Women have a 50% lifetime risk of developing breast cancer ...............

Read on ..............

Colon Lymphoma

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Q) A 55-year-old male patient presents with chronic abdominal pain, weight loss, and intermittent diarrhea. Colonoscopy reveals a mass in the cecum, and biopsy confirms colonic lymphoma. Which of the following statements is most likely true regarding this condition?

A) Colonic lymphoma is predominantly of T-cell origin
B) It is more common in females
C) The cecum is the most common site of involvement
D) It typically presents in the 3rd and 4th decades of life

C) The cecum is the most common site of involvement

Explanation:

Colonic lymphoma is a rare form of lymphoma that primarily affects the gastrointestinal tract. Among the options provided:

  • A) Colonic lymphoma is predominantly of T-cell origin: This is incorrect. Colonic lymphoma is most commonly of B-cell origin, particularly extranodal marginal zone lymphoma (MALT lymphoma), rather than T-cell lymphoma.
  • B) It is more common in females: This is also incorrect. Colonic lymphoma does not have a strong gender predilection. The incidence is more balanced between males and females.
  • C) The cecum is the most common site of involvement: This is correct. The cecum is the most frequent site of involvement in colonic lymphoma, especially for extranodal B-cell lymphoma, such as MALT lymphoma. It tends to present as a mass-like lesion, often causing symptoms such as abdominal pain and weight loss.
  • D) It typically presents in the 3rd and 4th decades of life: This is incorrect. Colonic lymphoma is more commonly diagnosed in older adults, typically over the age of 50. It is relatively rare in younger individuals.

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