CDH 1 gene

Q) CDH 1 gene is associated with which cancer

a) Breast

b) Colon

c) Prostate

d) Renal

ANs a CDH 1 is with gastric and lobular breast cancer

Germline mutation in the CDH1 gene encoding E-cadherin was shown to be associated with hereditary diffuse gastric cancer. Prophylactic total gastrectomy should be considered in patients with these mutations

Renal mainly associated with VHL


Q) Not seen in cowden syndrome
B. Hamartoma
C. CA breast
D. Bowel malignancy

Malignancy risk in CS is significant outside the GI tract. Women have a 50% lifetime risk of developing breast cancer ...............

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