Metastatic NET

Q) Girl with pain upper abdomen.  CT Abdomen shows  4 X 5 cm mass in segment V  and thickening in ileocecal region.
Liver Biopsy shows NET. Next line of management:?
A. Dotanoc
B. Colonoscopy
C. PET CT 
D. Surgery of liver

Loss of cell Surface antigen

Q) Loss of cell surface antigen is a feature of 
A. CIS
B. NO RELATION WITH GRADE
C. LOW GRADE TUMOR
D. HIGH GRADE TUMOR

Ans d High grade

The ABO(H) blood group system consists of terminal oligosaccharide antigens carried by glycoproteins or glycolipids in hematopoietic or epithelial cells 

Their biosynthesis is presumed to be controlled by the ABO(H), Se, H, Le, and X blood group genes .

These antigens are present on normal bladder epithelium of secretor individuals but not on some low-grade and early-stage papillary urothelial carcinomas 

Moreover, initially expressing tumours lose these cell surface antigens upon local recurrence, progression to invasion or metastization 

Papillary carcinoma thyroid

Q) 40yr old lady 2X 2 Solitarty thyroid nodule left lobe. FNAC shows  classic type of papillary  carcinoma . Usg no neck nodes. Management

A. Total thyroidectomy
B. Total thyroidectomy with Radio active Iodine
C. Total thyroidectomy with central compartment neck dissection
D. Hemithyroidectomy + follow up