Sentina Trial

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Q) According to SENTINA trial how many minimum sentinel lymph nodes to be removed (Onco 2019) A. 1 B. 2 C. 3 D. 4 Other Onco Mcqs

natural history breast cancer

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Q. True about breast cancer is? a) Doubling time of breast tumor is 1 month b) Skip metastasis in level iii lymph nodes is common c) Lungs are commonly involved by direct invasion d) Dimpling of skin is due to shortening of cooper’s ligaments Ans 

CDH 1 mutation

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Q ) Hereditary diffuse Gastric carcinoma is associated with which  breast cancer A. Ductal carcinoma NOS subtype B. Lobular carcinoma C. DCIS D. Metaplastic carcinoma Answer for Q 79 Majority of Gastric Cancers are sporadic, 1–3% of GCs arise as a result of inherited cancer predisposition syndromes.  Li-Fraumeni syndrome, Lynch syndrome, Peutz-Jeghers syndrome, hereditary breast and ovarian cancer,1MUTYH-associated adenomatous polyposis (MAP), familial adenomatous polyposis,  juvenile polyposis syndrome and PTENhamartoma tumour syndrome (Cowden syndrome). Read on for answer

Breast Cancer Management

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Q) Management of occult breast cancer with N1 lymph nodes: a) Modified radical mastectomy (MRM) with axillary dissection b) MRM with radiotherapy to axilla c) Only axillary dissection with radiotherapy and chemotherapy to axilla d) Simple mastectomy with chemotherapy Answer for premium members

Phyllodes tumor

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Q) Which of the following is true about phyllodes tumor? a) It has a fast spread and is locally invasive b) It is benign proliferative in ANDI c) Mammography is diagnostic d) Young patients less than 20 years old are more commonly involved answer for Premium members only-   Discuss about Phyllodes tumor and their malignant potential.

Ductal carcinoma in situ

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Q) IN RTOG trial for ductal carcinoma in situ (DCIS) favourable tumor was defined as a) <3,5 cm in size and 2mm free resection margin b) <2.5 cm and 2mm margin c) <3 cm size and 3 mm margin d) <2.5 cm size and 3 mm margin Answer – Free answers to surgery mcqs d Ductal carcinoma in situ is a pre invasive state in which the cancer cells have not breached the epithelial membrane. It can develop into cancer in 20%. Simple mastectomy is the standard of care but many centers now consider it over treatment. Van Nuys system uses Age of the patient type of DCIS presence of microcalcification Size resection margin On mammography this is seen as clustered clustered calcification Treatment options are  Mastectomy Breast conserving therapy (Lumpectomy +radiation and hormonal) More recently, Eastern Cooperative Oncology Group investigators reported the frst result of a relatively large prospective single-arm study of surgery with negative margins of at least 3 mm without radiation therapy for patients with favorable subsets of DCIS.  Patients with low-grade or intermediate-grade DCIS measuring 2.5 cm or smaller had a 5-year rate of ipsilateral breast recurrence of only 6.1%. In contrast, patients with high-grade disease had a much higher 5-year ipsilateral breast recurrence rate of 15.3%. REF : Sabiston 853 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334775/  

Inflammatory Carcinoma breast

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Q) In terms of cure best results in inflammatory carcinoma breast  are seen with- a) Surgery alone b) Chemotherapy c) Radiotherapy d) All of the above Surgery MCQ PDF – Free Answer d)  Inflammatory carcinoma of the breast is a rare aggressive tumor that blocks the sub dermal lymphatics as a result of which cutaneous edema is common . Differentiating it from a breast abscess is important and biopsy is diagnostic. It is also responsible to peau d orange Treatment is multidisciplinary and involves, chemotherapy followed by surgery followed by radiotherapy.