Q) MEN 2A also known as A. Sipple syndrome B. Wermer syndrome
C) Werner syndrome
Sipple and Steiner described the association of thyroid cancer with pheochromocytoma and hyperparathyroidism, respectively
Bailey says MTC combined with phaeochromocytoma alone is called Sipple’s syndrome (page 856)
MEN2A is characterized by MTC, pheochromocytoma (50%) and hyperparathyroidism (25%).
Associated with mutations in codon 634 in the RET proto-oncogene.
Wermer- MEN 1 is characterised by the triad of tumours in the anterior pituitary gland, mostly presenting as prolactinomas or non-functioning tumours, hyperplasia of the parathyroids causing primary hyperparathyroidism (pHPT) and pancreaticoduodenal endocrine tumours (PETs)
Patients with MEN 2B do not develop pHPT
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