Small Bowel Adenocarcinoma & its Risk Factors

Q) Which of the following is not a risk factor/ least associated with small bowel adenocarcinoma ?

a) Familial adenomatous polyposis (FAP)

b) Hereditary nonpolyposis colorectal cancer

c) Peutz-Jeghers syndrome

d) Juvenile polyposis coli


MOre Questions on Small Bowel Q 1-5

 

Ans

d

Juvenile Polyposis Coli is least associated with small bowel adenocarcinoma

Risk factors for Small bowel Adenocarcinoma are 

  1. Hereditary polyps - familial adenomatous polyposis (FAP), hereditary nonpolyposis
    colorectal cancer, Peutz-Jeghers syndrome

2.  Crohn disease, gluten-sensitive enteropathy (i.e., celiac sprue), prior peptic ulcer disease, cystic fibrosis, and biliary diversion (i.e., previous cholecystectomy).

3. Lifestyle

Smoking, heavy alcohol consumption (>80 g/day of ethanol), and consumption of red meat or salted food

4. Genetic -

Kras,  5q (APC gene), 17q (p53 gene), and 18q  and DPC4 , SMAD 4, MSI H

Sabiston page 1274

 

Virchow’s triad

Q) Which of the following does not form a part of Virchow's triad?

a) Endothelial damage

b) Slow blood flow

c) Platelet defects

d) Hypercoagulable state


"More Questions on Periop Management"

c Platelet defects

Virchow triad (venous stasis, endothelial injury, and hypercoagulability) describes the factors contributing to venous clot formation and thromboembolism

Platelet defects are associated with arterial thrombosis and not venous

He is known as "the father of modern pathology" and as the founder of social medicine, and to his colleagues, the "Pope of medicine"

Antigen Presenting cells

Q) Most potent cells that present antigen and are distributed throughout the lymphoid and nonlymphoid tissues of the body are??

a) Dendritic cells

b) Natural killer cells

c) Macrophages

d) Monocytes

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Ans a 

Dendritic cells are specialized macrophages that are regarded as professional APCs. They are the most potent cells that present antigen

NK cells ( part of innate immunity) are large granular lymphocytes with potent cytolytic function that constitute a critical component of innate immunity.

Sabiston 575

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Paclitaxel group drugs

Q)  Which group of drug paclitaxel belongs to ? 
a) Drugs which interfere with mitosis
b) Antimetabolites ( those which interfere with DNA synthesis)
c) Drugs which directly damage DNA
d) Inhibitor of  receptor tyrosine kinase


Check Questions from Neet onco 2020 exam

 Drugs in onco  asked in exams

Ans a )

Paclitaxel is a drug which interferes with mitosis. It is a class of drug which interferes with mitosis
Vincristine is also in the same group but it interferes with formation of microtubules ( Spindle poison)
Antimetabolites are 5 FU, Methotrexate, Gemcitabine
Drugs which damage DNA Mitomycin , Cisplatin, oxaliplatin, doxorubicin
Receptor tyrosine kinase inhibitor are Imatinib, Geftinib
ref page 156 Bailey 

Trace elements deficiency

Q ) Which of the following trace elements deficiency causes impaired glucose tolerance, anemia, neutropenia and leukopenia ( Question as per NEET SS 22 Syllabus) 

a) Zinc

b) copper

c) Molybdenum

d) Selenium

MCQs on Nutrition and Periop management

Ans ) B Copper

Copper Promotes cross-linking of collagen and elastin synthesis and  scavenges free radical

Its deficiency causes Skeletal demineralization, impaired glucose tolerance, anemia, neutropenia,
leukopenia, changes in skin and hair pigmentation also it is linked to fatal arrhythmias

Ref Sabiston 21 st page 110

Necrotising Infections

Q)  Least common Signs or symptoms of necrotising infections is
a) Unusual pain
b) Oedema beyond area of erythema
c) Crepitus
d) Fever

( MCQS on infections bailey and Sabiston based) 

Ans d 

Fever is unusual

Signs and symptoms of necrotising infections
● Unusual pain
● Oedema beyond area of erythema
● Crepitus
● Skin blistering
● Fever (often absent)
● Greyish drainage (‘dishwater pus’)
● Pink/orange skin staining
● Focal skin gangrene (late sign)
● Shock, coagulopathy and multiorgan failure

Ref Bailey 27th page 30

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