Paclitaxel group drugs

Q)  Which group of drug paclitaxel belongs to ? 
a) Drugs which interfere with mitosis
b) Antimetabolites ( those which interfere with DNA synthesis)
c) Drugs which directly damage DNA
d) Inhibitor of  receptor tyrosine kinase
Neet onco 2020
 Drugs in onco 

Ans a )

Paclitaxel is a drug which interferes with mitosis. It is a class of drug which interferes with mitosis
Vincristine is also in the same group but it interferes with formation of microtubules ( Spindle poison)
Antimetabolites are 5 FU, Methotrexate, Gemcitabine
Drugs which damage DNA Mitomycin , Cisplatin, oxaliplatin, doxorubicin
Receptor tyrosine kinase inhibitor are Imatinib, Geftinib
ref page 156 Bailey 

Trace elements deficiency

Q ) Which of the following trace elements deficiency causes impaired glucose tolerance, anemia, neutropenia and leukopenia ( Question as per NEET SS 22 Syllabus) 

a) Zinc

b) copper

c) Molybdenum

d) Selenium

MCQs on Nutrition and Periop management

Ans ) B Copper

Copper Promotes cross-linking of collagen and elastin synthesis and  scavenges free radical

Its deficiency causes Skeletal demineralization, impaired glucose tolerance, anemia, neutropenia,
leukopenia, changes in skin and hair pigmentation also it is linked to fatal arrhythmias

Ref Sabiston 21 st page 110

Necrotising Infections

Q)  Least common Signs or symptoms of necrotising infections is
a) Unusual pain
b) Oedema beyond area of erythema
c) Crepitus
d) Fever

( MCQS on infections bailey and Sabiston based) 

Ans d 

Fever is unusual

Signs and symptoms of necrotising infections
● Unusual pain
● Oedema beyond area of erythema
● Crepitus
● Skin blistering
● Fever (often absent)
● Greyish drainage (‘dishwater pus’)
● Pink/orange skin staining
● Focal skin gangrene (late sign)
● Shock, coagulopathy and multiorgan failure

Ref Bailey 27th page 30

Adenoid Cystic Tumors

Q) All are true for adenoid cystic tumor of the hard palate except

a) Perineural invasion

b) Lung metastasis

c) Lymph node metastasis

d) Increased risk of local recurrence

Ans c 

Adenoid cystic carcinoma is a rare tumor arising from the minor salivary glands;, the palate being the commonest site.

Distant metastasis and perineural invasion are common in adenoid cystic carcinoma.

The lesion is uncapsulated and infiltrative; invasion of underlying bone is common.

Incidence of cervical metastasis is low.

Distant metastasis occurs through blood stream to lung and bones. Direct extension of lesion of the base of skull has been reported as a cause of death.

Ref - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633292/

MCQ on General onco

Q) WHich is not a invasive mechanism of cancer cells invasion ?

a) Rise in interstitial pressure in the tissue

b) Dissolution of extracellular matix

c) Mobility of cells to Invade

d) Extra cellular matrix dissolution is due to  physical factors

Ans d 

Cancer cells secrete collagenases and proteases that chemically dissolve any extracellular boundaries
They also express  of cell-surface molecules called integrins

Three main mechanisms of cancer cells  that  facilitate invasion are

(1) Rise in the interstitial pressure within a tissue

2. They secrete enzymes that dissolve extracellular matrix

3. Acquire mobility

bailey 141

Differential diagnosis of mass in right iliac fossa

Q) Patient with generalized ill health and pyrexia has a mass in the right iliac fossa with a history of blood-stained mucoid diarrheia? Most common etiology in this case would be ? 

a) Carcinoma

b) TB

c) Amoeboma

d) Lymphoma

More questions on general surgery tropical infections

Ans  c

Amoeboma is partially treated amoebic infection of the caecum

It mostly presents as a mass in RIF and causes confusion with malignancy.

Such a patient is highly unlikely to have a carcinoma because altered bowel habit is not a feature of right-sided colonic carcinoma.

Ref Bailey page 58

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