Carcinoma GB epidemiology

Q) Not true about GB malignancy

A. 80 percent of porcelain gall bladder predispose to malignancy

B. Untreated advanced  CA GB  median survival is 2-5 months

C. Stippled calcification of mucosa has higher risk of malignancy than diffuse intramural calcification

D. More than 75 percent of CA gall bladder has history of cholelithiasis

 

Ans a 

69% to 86% of patients with gallbladder cancer have a personal history of gallstone disease.

The presence of an abnormal pancreaticobiliary duct junction, thought to promote chronic biliary inflammation, has been associated with both choledochal cyst disease and gallbladder cancer.

In porcelain gallbladder, risk of ca gb due to chronic inflammation and calcification of the gallbladder wall, was once estimated to be as high as 61%; however, more contemporary analyses suggest that the correct figure is more likely between 7% and 25%

Ref Shackelford 8th page 1323

VON Hipple

Q)Von Hippel Lindau (VHL) causes all except
1. breast cancer
2. pancreas cancer
3. renal
4. hemangioma of cerebellum