CDH 1 mutation

Q ) Hereditary diffuse Gastric carcinoma is associated with which  breast cancer
A. Ductal carcinoma NOS subtype
B. Lobular carcinoma
D. Metaplastic carcinoma

Answer for Q 79

Majority of Gastric Cancers are sporadic,

1–3% of GCs arise as a result of inherited cancer predisposition syndromes.

 Li-Fraumeni syndrome, Lynch syndrome, Peutz-Jeghers syndrome, hereditary breast and ovarian cancer,MUTYH-associated adenomatous polyposis (MAP), familial adenomatous polyposis,  juvenile polyposis syndrome and PTENhamartoma tumour syndrome (Cowden syndrome).

Read on for answer


Q) All are true about Glucagonoma except

a) Usually seen  in middle age and elderly

b) Usually > 5cm at presentation

c) Skin lesions preceed tumor detection by 6-8yrs

d) Often associated with ketoacidosis

Glucaonoma is an endocrine tumor characterized by increased levels of serum glucaogon. It is seen in the age group ............... Read on   (Question 8) 

For other questions on endocrine tumors


Q) Regarding gastrinoma what is true? ( # Questions on Endocrine Surgery) 

a) All gastrinomas express SRS receptors

b) In 30 % of cases gastrinomas are not localized intra operatively

c) Levels of serum  gastrin more than 100pg/ml are strongly suggestive of gastrinoma

d) Angiography with secretin stimulation is required in all cases for localization of gastrinoma


EUS in pancreatic cancer

Q) What is true about the role of EUS in Carcinoma head of pancreas.

a) It has a sensitivity of 50-60% in detecting lesions less than 3 cm in size

b) It has a  high negative predictive  value

c) Chronic pancreatitis can be easily differentiated from Carcinoma head of pancreas by EUS

d) Small caliber needles have low accuracy than high caliber needles in FNAC