Anti rejection drugs
Posted onQ) Anti Rejection medicine which also prevents tumor recurrence? MCH Questions ...
a) M tor inhibitors
b) IL2 blockers
c) Steroids
d) Azathioprine
a) M tor inhibitors
b) IL2 blockers
c) Steroids
d) Azathioprine
Q) Which of the following is not done in small for size syndrome in liver transplant
a) Splenectomy
b) Hemi porto caval shunt
Q) False regarding immunosuppresant medicines ?
a. MMF is a reversible inhibitor of IMD-DH
b. Both Cyclosporine and tacrolimus inhibit NF-KB and its downstream effects
c. Everolimus acts on FKBP12To inhibit Calcineurin activity
d. ALG are more used in pancreas transplant
Q) Not true about ciclosporin use in liver transplant
a) It exerts its effect the same way as tacrolimus
b) Nephrotoxicity is the main notable side effect
c) Both tacrlimus and ciclosporin have equal rates of preventing acute rejection
d) Hypetrension, DM and dyslipidemia are other common side effects
Q) Which of the following is false regarding HLA in graft rejection?
a) HLA (Human leucocyte antigen) is the most common cause of graft rejection
b) They mainly serve as antigen recognition unit
c) HLA also serve as effector cells
d) They are highly polymorphic
Q ) Most common indication for Pediatric liver transplant (DNB SS)
A. Biliary atresia
B. Metabolic diseases
C. Alagille syndrome
D. HCV
a
Biliay atresia
MOst common cause or liver transplant in children.
Presents as persistent jaundice after birth. Etiology is not clear
Findings include absent extrahepatic ducts and gallbladder.
Biopsy is diagnostic
Q ) Most common malignancy in post-transplant individuals
A. PTLD
B. Skin- Squamous cell carcinoma
C. Kaposi sarcoma
D. CNS Lymphoma
Q) Causes of primary graft non function are A/E
a) Recipient with renal failure
b) Microsteatosis > 60%
c) Cold ischaemia time > 12hrs
d) Non heart beating donor
Discuss the causes of PNF-Primary non function of liver
Q) Banff Scoring system is for
a) Acute pyelonephritis
b) Chronic glomerulonephritis
c) Acute Rejection
d) Chronic renal graft rejection
Discuss what is banff score
What is the need of banff score
What are the components
What is the significance
Q ) False about lymphoproliferative disorders after solid organ transplant
a) Viral etiology is common
b) More common where doses of immunosuppression is more
c) Children are affected more than adults
d) T cell cycle is stimulated abnormally
a) Portal vein thrombosis is more common than Hepatic Artery thrombosis
b) Bile leak though common is not a significant problem
c) Any bleeding in post op period, patient should be taken to OT
d) Acute liver rejection is seen in 5-10% cases