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Q1) False about the use of propofol as anesthetic drug in surgery
a) It is short acting and used in Iv sedation
b) It is a good analgesic and preferred in all surgeries
c) Propofol infusion syndrome is rare but fatal
d) Propofol is a bronchodilataor
Ans1 b
Propofol is a short-acting induction agent that is associated with smooth, nausea-free emergence. It also causes fall in BP.
It also causes bronchodilatation. Propofol or ketamine is often chosen as an alternative for induction in patients with reactive airways disease
Benzodiazepines and propofol have long been the key agents used for sedation, but they provide no analgesia,
Propofol causes vasodilation and significant redistribution hypothermia.
(TIVA) is administration of propofol in combination with opioids
Propofol, also a GABA agonist, has rapid onset and clearance
Propofol is lipid based and can lead to
hypertriglyceridemia,
pancreatitis,
Propofol infusion syndrome. The propofol infusion syndrome must be recognized early because it has a very high mortality; patients typically present with severe metabolic derangements, including rhabdomyolysis, acute kidney injury (AKI), metabolic acidosis, and shock
Q2) The following drug has been shown to improve long term survival after major surgery
A. Calcium channel blockers
B. ACE inhibitors
C. Beta blockers
D. ISDN
Ans 2 c
Ans is C- beta blockers
In concepts behind ERAS (enhanced recovery after surgery), modulating stress/inflammatory response at the time of surgery may have long term.sequelae over periods of months or longer. For eg; beta blockers and statins have been shown to improve long term survival after major surgery. These effects may be due to suppression of innate immunity at the time of surgery.
