Familial Adenomatous Polyposis (FAP)
- Autosomal dominant, APC gene chromosome 5q21
- Multiple colonic polyps, stomach polyps, duodenal and periampullary cancers
- Extra intestinal manifestations occur in FAP- desmoid abdomen, osteomas, epidermoid cyst, brain tumors
- Duodenal polyps are pre malignant
- Other malignancies are predisposition to GB cancer, bile ducts, pancreas, adrenal, thyroid
Subtypes of FAP are Gardner and Turcot
Gardner has CEO - (colonic polyps, epidermal inclusion cysts, osteomas)
Turcot - Colon polyps and Brain tumors