9. Q) What is not true regarding Ultrasound Microbubble Contrast Agents in detecting focal lesions in the liver
Contrast Enhanced Ultrasound is a new modality which consists of injecting contrast bubbles in the circulatuion and as these contrast get adherent to the Kupffer cells of liver, they emit acoustic signals which are then picked up by the USG probe.
Now 2nd generation contrast bubbles are available that emit acoustic signals as they contract and expand. These bubbles remian in circulation and detection of arterial and portal phase becomes easier
Advantages over CT scan are
1 the microbubble contrast agents are real blood-pool agents not leaving the intravascular space
2 A continuous imaging over the whole enhancement period with high temporal resolution is possible, not limited to distinct, pre-defined time points
Other advantages are no exposure to radiation, absence of nephrotoxic contrast agents and large availability of machines.
In comparison with CT and/or dynamic MRI, SonoVue®-enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate.
(Ref)Hervé Trillaud Characterization of focal liver lesions with SonoVue®-enhanced sonography: International multicenter-study in comparison to CT and MRI . World J Gastroenterol. 2009 August 14; 15(30): 3748–3756.