Pathology of Lung cancers
Important points about lung cancer
Lung cancers are traditionally divided into
- non–small cell carcinoma (NSCC)
2. small cell carcinoma (small cell lung carcinoma, SCLC),
Former accounting for 80% of the cases and the latter accounting for the remaining 20%
Major types of NSCC include
Adenocarcinoma - Most common, Most common presentation peripherally located mass with central fibrosis and pleural puckering.
Lung adenocarcinoma cells usually express pneumocytic markers.
Thyroid transcription factor (TTF-1) and NapsinA are expressed in more than 85% of the lung adenocarcinoma
Squamous cell carcinoma (SSC), SCC usually occurs in the central portion of the lung, along major airways, and can form cavities when it achieves a large size.
large cell carcinoma (LCC) Peripheral
Target ted therapy
EGFR mutation and ALK translocation are the most effectively targeted oncogenes in NSCC and are now considered standard of care.