MCH onco Surgery questions 2021

Q1. Brca positive breast cancer  - therapy is?

A) Olaparib
B) Trastuzumab
C) Tamoxifen

Ans a) Olaparib is PARP  inhibitor

Tamoxifen is for ER PR +

Trastuzumab is anti HER 2 for breast cancer with HER 2/neu

Sabiston page 662

Q2)  High risk ca breast ie 20-25% does not include 

a) BRCA 1 or BRCA 2 mutation

b) Radiation therapy to breast between 10-30 yrs

c) Li Fraumeni syndrome

d) Atypical ductal hyperplasia

Ans d )

Women at Moderately Increased (15%–20%) Lifetime Risk include any of the following
1. Personal history of breast cancer, ductal carcinoma in situ, lobular carcinoma in situ, atypical ductal hyperplasia, or atypical lobular hyperplasia
Sabiston 819


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