Q1. Brca positive breast cancer - therapy is?
A) Olaparib
B) Trastuzumab
C) Tamoxifen
Ans a) Olaparib is PARP inhibitor
Tamoxifen is for ER PR +
Trastuzumab is anti HER 2 for breast cancer with HER 2/neu
Sabiston page 662
Q2) High risk ca breast ie 20-25% does not include
a) BRCA 1 or BRCA 2 mutation
b) Radiation therapy to breast between 10-30 yrs
c) Li Fraumeni syndrome
d) Atypical ductal hyperplasia
Ans d )
Women at Moderately Increased (15%–20%) Lifetime Risk include any of the following
1. Personal history of breast cancer, ductal carcinoma in situ, lobular carcinoma in situ, atypical ductal hyperplasia, or atypical lobular hyperplasia
Sabiston 819