Q) Which is not a mechanism of cancer cells invasion ?
a) Rise in interstitial pressure in the tissue
b) Dissolution of extracellular matrix
c) Mobility of cells to Invade
d) Extra cellular matrix dissolution is due to physical factors
Ans d
Cancer cells secrete collagenases and proteases that chemically dissolve any extracellular boundaries
The three main mechanisms by which cancer cells facilitate invasion are:
Dissolution of Extracellular Matrix: Cancer cells secrete proteolytic enzymes, such as matrix metalloproteinases (MMPs), that break down components of the extracellular matrix. This dissolution allows cancer cells to penetrate surrounding tissues.
Acquisition of Mobility: Cancer cells gain enhanced motility, which enables them to move through tissues. This involves changes in cell adhesion properties and the cytoskeleton that promote movement.
Rise in Interstitial Pressure: While increased interstitial pressure can affect fluid dynamics within tissues, it is typically a consequence of tumor growth rather than a mechanism that facilitates invasion. Thus, it's important to clarify that this is not a primary mechanism for invasion.
