Important points for NEET SS- General Surgery
- Proinflammatory cytokines including interleukin1 (IL1), tumour necrosis factor alpha (TNFα), IL6 and IL8 are produced within the first 24 hours and act directly on the hypothalamus to cause pyrexia.
- Under extreme conditions of catabolism (e.g. major sepsis), urinary nitrogen losses can reach 14–20 g/da 500 g of skeletal muscle per day. Muscle catabolism cannot be inhibited fully by providing artificial nutritional support as long as the stress response continues.