Q) Which of the following is Not a risk factor for pouchitis post IPAA in ULcerative colitis
A) Smoking
B ) NSAIDs use post op
C) Elderly patients
D) UC with extra intestinal manifestation
Ans a
Pouchitis is the complication of Ileal Pouch Anal Anastomosis (IPAA) for Ulcerative colitis. The incidence of pochitis for the same proedure for familial Adenomatous polyposis is less than 10% but for ulcerative colitis can go as high as 50%.
Risk factors for development of pouchitis are
- Previous extra intestinal manifestations of IBD especially arthritis
- ANCA positive cases of UC
- NOD2insC positive patients
- Smoking prevents the development of puchitis after IPAA in ulcerative colitis.
5. Other reported factors that may associate with pouchitis include extent of UC, thrombocytosis,and PPI use with NSAId
Ref - https://onlinelibrary.wiley.com/doi/full/10.1111/den.12744