Small Bowel Adenocarcinoma & its Risk Factors

Q) Which of the following is not a risk factor/ least associated with small bowel adenocarcinoma ?

a) Familial adenomatous polyposis (FAP)

b) Hereditary nonpolyposis colorectal cancer

c) Peutz-Jeghers syndrome

d) Juvenile polyposis coli

MOre Questions on Small Bowel Q 1-5




Juvenile Polyposis Coli is least associated with small bowel adenocarcinoma

Risk factors for Small bowel Adenocarcinoma are 

  1. Hereditary polyps - familial adenomatous polyposis (FAP), hereditary nonpolyposis
    colorectal cancer, Peutz-Jeghers syndrome

2.  Crohn disease, gluten-sensitive enteropathy (i.e., celiac sprue), prior peptic ulcer disease, cystic fibrosis, and biliary diversion (i.e., previous cholecystectomy).

3. Lifestyle

Smoking, heavy alcohol consumption (>80 g/day of ethanol), and consumption of red meat or salted food

4. Genetic -

Kras,  5q (APC gene), 17q (p53 gene), and 18q  and DPC4 , SMAD 4, MSI H

Sabiston page 1274


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