MCQ Review of SCLC
Etiology of SCLC
- Smoking (97% cause)
Small cell carcinomas or SCLCs comprise slightly more than 10% of all lung cancers.
SCLC is a highly aggressive malignancy
Patients usually have metastatic disease at the time of presentation.
Most patients relapse within the first 2 years after treatment and the
2-year survival rate is less than 10% in metastatic patients
Constitutional - Fatigue, weight loss,
Pumonary - Large central mass invading or compressing the mediastinum
Superior vena cava obstruction has been 10% of patients with SCLC.
Chest imaging hilar and mediastinal adenopathy
3. Extra pulmonary- Hepatic and adrenal- asymptomatic.
Brain metastases, 18% of patients often asymptomatic.
Bone involvement asymptomatic osteolytic lesions
4. Paraneoplastic- SIADH, Cushing Syndrome, Hypercalcemia