MCQ Review of SCLC

Smoking (97% cause)

Clinical Features

Small cell carcinomas or SCLCs comprise slightly more than 10% of all lung cancers.

SCLC is a highly aggressive malignancy

Patients usually have metastatic disease at the time of presentation.

Most patients relapse within the first 2 years after treatment and the
2-year survival rate is less than 10% in metastatic patients

Constitutional - Fatigue, weight loss,

Pumonary - Large central mass invading or compressing the mediastinum

Superior vena cava obstruction has been 10% of patients with SCLC.

Chest imaging hilar and mediastinal adenopathy

3. Extra pulmonary- Hepatic and adrenal- asymptomatic.

Brain metastases, 18% of patients often asymptomatic.

Bone involvement asymptomatic osteolytic lesions

4. Paraneoplastic- SIADH, Cushing Syndrome, Hypercalcemia