Q) Not used in steroid refractory severe Ulcerative Colitis ( AIIMS 2020 Nov)
a) Infliximab b) Azathioprine c) Cyclosporine d) Surgery
Ans b- Azathioprine
Cyclosporine is immunomodulator indicated for second-line therapy in the case of severe, steroid refractory ulcerative colitis. Treatment is usually initiated after 3 to 5 days of failed steroid response
Tacrolimus is appropriate as second-line therapy in patients with severely active ulcerative colitis unresponsive to steroids.
The use of various anti–tumor necrosis factor-α (TNF-α) monoclonal antibodies ( infliximab) is well supported in the case of severe ulcerative colitis refractory to steroids.
