Q) True about lymphoma of the colon?
a) More common in females
b) Most common in 3rd and 4th decade
c) Most common site is caecum
d) T cells are most commonly involved
Colon Lymphoma Pathology Outlines
Extranodal Marginal Zone B-Cell Lymphoma
ENMZL, formerly known as marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Low-grade lymphoma involving cells that arise from the marginal zone surrounding lymphoid follicles.
23%–48% of all primary GI NHLs, second only to DLBCL in most series
ENMZLs are heterogeneous lymphomas, often containing monocytoid-like cells, plasma cells, and scattered large cells intermixed with marginal zone cells.
There are small cells with irregular cleaved nuclei and a moderate amount of clear cytoplasm
Microscopic Appearance diffuse sheets of large lymphoid cells infiltrate the lamina propria and submucosa, with frequent obliteration of the muscularis propria and ulceration of the overlying mucosa.
Irregular nuclei, prominent nucleoli, and basophilic cytoplasm and are more than twice as large as normal lymphocytes.
Other less common type is Mantle cell lymphoma
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